Tina Huang. But she came up with a way to break down the code and create a website that she was proud of. J. Archaeol. 2010, pdb.prot5448 (2010). Moreover, previous studies have shown that El Mirn carries a genetic contribution from the Villabruna cluster, which is found in Epigravettian-associated individuals from Italy4,15. I am super excited to join the 365 Data Use Cases series, and in this post, I will share insights about my favorite data use case: product development. The two 14ka Oberkassel individuals mark the earliest presence of WHG ancestry north of the Alps, which we therefore rename the Oberkassel cluster(hereafter, Oberkassel cluster or ancestry), using the name of the oldest reported individual to date carrying such ancestry with more than one-fold coverage, for consistency4. After a period of limited admixture that spanned the beginning of the Mesolithic, we find genetic interactions between western and eastern European hunter-gatherers,who were also characterized by marked differences in phenotypically relevant variants. In no time, she established herself as one of the favorite vloggers of the data community. J. Fu, Q. et al. Extended Data Fig. To obtain Kozowski, S. K., Potowicz-Bobak, M., Bobak, D. & Terberger, T. New information from Maszycka Cave and the Late Glacial recolonisation of Central Europe. Youth Vaping_ An Analysis of an Epidemic.pdf - Georgia 15, 22792300 (2020). "It is possible that the migration of early farmers into Europe triggered the retreat of hunter-gatherer populations to the northern edge of Europe. Curr. Both double-stranded and single-stranded libraries were further amplified with IS5/IS6 primers to reach a concentration of 200400ng/l as measured on a NanoDrop spectrophotometer (Thermo Fisher Scientific). BMC Res. Brunel, S. et al. Upper Palaeolithic Siberian genome reveals dual ancestry of Native Americans. 7,794 followers. Hi, my name is Tina and I'm a data scientist at a FAANG company. English company number 3898053New York | Boston | Chicago | Austin | Toronto | Brighton | London | Copenhagen | Berlin | Stuttgart | Frankfurt | Paris | Madrid | Budapest | Sofia | Chennai | Singapore | Sydney | Melbourne. The version used for this work is archived at https://edmond.mpdl.mpg.de/dataset.xhtml?persistentId=doi:10.17617/3.Y1KJMF. 10, 552010 (2019). My name is Tina and I'm a data scientist and YouTuber. A subset of samples (GER002 and GER003) were pre-treated with a washing step to reduce surface contamination54. Int. Created by DataSciencePR. Lifetime access to all course materials and updates. "The data we gained from this study provides us with astonishingly detailed insights into the developments and encounters of West Eurasian hunter-gatherer groups," Posth summarises. "Further interdisciplinary research will clarify which exact processes were responsible for the genetic replacements of entire Ice Age populations.". Quat. Open access funding provided by Max Planck Society. 16, e2003703 (2018). Enjoy maximum flexibility and forget about cramming against the clock. The libraries underwent shallow shotgun sequencing on an Illumina HiSeq 4000 instrument with 75 single-end-run cycles using the manufacturers protocol, to evaluate the human endogenous DNA content and quality. Yu Ting Wang, Wen Lin Huang, Yan Ting Cheng. Modern humans left sub-Saharan Africa at least 60 thousand years ago (ka), and during their initial expansion into Eurasia, they genetically mixed with Neanderthals, resultingin 23% Neanderthal ancestry in the majority of present-day non-African populations5. The images or other third party material in this article are included in the articles Creative Commons license, unless indicated otherwise in a credit line to the material. Hutong Cat | China and Russia's invasion of Ukraine: A year later Error bars show 1s.e.m. From at least 14,000 years ago, an ancestry related to this culture spread from the south across the rest of Europe, largely replacing the Magdalenian-associated gene pool. Extended Data Fig. 5b and Supplementary Figs. Both of these books focus on the science and math behind data mining. Fu, Q. et al. The levels of contamination from modern human DNA were estimated on the basis of mitochondrial DNA (mtDNA), X chromosome and autosomal DNA, and with a haplotype copying model that is extended here to autosomal data in runs of homozygosity (ROH) (Methods, Supplementary Information, sections2 and 3, Supplementary Figs. b, Allele frequencies of different hunter-gatherer groups (coloured dots) on four SNPs related to skin colour (SLC24A5 and SLC45A2), eye colour (HERC2/OCA2) and lactase persistence (LCT). Therefore,most of the ancestry found in these post-LGM individuals probably traced back to Gravettian-associated groups from western and southwestern Europe. Ancient genomes show social and reproductive behavior of early Upper Paleolithic foragers. Ecol. Saag, L. et al. While terms such as lithic industry, techno-complex, prehistoric tradition, and so on might be more appropriate to refer to the various associated chrono-cultural subdivisions, they concern different levels of discussion and are not applicable to all contexts investigated here. Tina Zhang - Brand Specialist - Dymind Biotechnology | ZoomInfo PubMed A draft sequence of the Neandertal genome. A hands-on course covering SQL setup and fundamental components, combined with a guided walkthrough of 10 mock interviews with real-world SQL interview questions and expert tips on how to pass them successfully. Therefore, contrary to previous suggestions34, this demonstrates that the post-LGM diffusion of the Magdalenian was indeed associated with northward and northeastward population expansions from western Europe35. a, The genetic ancestry of hunter-gatherers dated between 14ka and 5.2ka modelled using qpAdm, with Oberkassel, Yuzhniy Oleniy Ostrov, Goyet Q-2 and Neolithic farmers from present-day Turkey (Barcn, Mentee and Boncuklu sites) representing Oberkassel (WHG) (blue), Sidelkino (EHG) (red), GoyetQ2 (orange) and Anatolian Neolithic farmer (green) ancestries, respectively. Gansauge, M., Aximu-Petri, A., Nagel, S. & Meyer, M. Manual and automated preparation of single-stranded DNA libraries for the sequencing of DNA from ancient biological remains and other sources of highly degraded DNA. We applied ANGSD 0.93470 and hapCon71 for libraries from male individuals, and applied contamLD72 and a newly developed method that analyses contamination in ROH for female and male libraries (see Supplementary Information, section2 for a detailed description). She then served as a postdoctoral associate at the National Institute of Standards and Technology. Schubert, M., Lindgreen, S. & Orlando, L. AdapterRemoval v2: rapid adapter trimming, identification, and read merging. Christina Yu-Ting Wang - Design Team Lead - TomTom | LinkedIn Learn with a sense of purpose. Questions? It is not intended to provide medical or other professional advice. Science 346, 11131118 (2014). However, published Gravettian-associated genomes originate from central and southern Europe, leaving the genetic profile of Gravettian-associated humangroups from western and southwestern Europe undescribed. 15, 193223 (2005). Illumina sequencing platforms were also used to sequence the 1240k and mtDNA captured libraries (Supplementary Data 1.B). Raghavan, M. et al. Biol. Curr. Lipson, M. et al. This suggests that genetic links between southern and southwestern European hunter-gatherers around the time of the LGM extended north of the Pyrenees. Nakatsuka, N. et al. However, one of my favorites is using supervised learning techniques, such as random forest, SVM, and XGBoost, to discover which features contribute the most to the success of a product. Opin. Protoc. In central Europe, admixture with ANF ancestry became highly common but not ubiquitous, indicating the co-existence of hunter-gatherer and farmer societies without admixing for several hundred years. of estimates from 5-cM-block jackknife analysis. The incoming Villabruna ancestry later became the most widespread hunter-gatherer ancestry across Europe. Large-scale genomic analysis documents the migrations of Ice Age hunter-gatherers over a period of 30,000 years -- they took shelter in Western Europe but died out on the . Showcase your skills and bolster your data science credentials. Mid and Late Upper Palaeolithic in the Adriatic Basin: chronology, transitions and human adaptations to a changing landscape. Curr. Genetic ancestry changes in Stone to Bronze Age transition in the East European plain. Tina Huang I'm a data scientist, youtuber, and the first Lonely Octopus . Tina Huang Popularity . Posth, C., Yu, H., Ghalichi, A. et al. Lcuyer, C., Hillaire-Marcel, C., Burke, A., Julien, M. A. Article After 7.5ka, as ANF ancestry had reached regions north of the Alps, individuals carrying a hunter-gatherer genetic profile were primarily restricted to the northern fringes of Europe (Fig. The tree was calculated on 16,528 positions (partial deletion 95%) and with 500 bootstrap iterations using MEGA1097. I'm interested in tech, trading, and how to minimize effort and maximize outcome. In this admixture graph, the lineage related to Zlat k splits more basally than the Bacho Kiro IUP group, who contributes to Tianyuan, UstIshim and Goyet Q116-1 (indicated with red lines), but not to the Sunghir group. In anticipation of possible near-term approval from the US Food and Drug Administration for renal denervation, there must be an insistence on longer-term clinical outcomes and safety data. You'll likely won't meet her on a day to day basis, but she's always lurking in the Discord and following everybody's progress (not . Tina K. Sorensen. At this startup dedicated to b2b marketing, we, the data team formed by 2 people, are organizing all the data from zero and looking for their real value. Surprisingly, however, none of those pre-40ka individuals left substantial traces in the genetic makeup of present-day Eurasian populations1,2,6,7. Google Scholar. We then attempted to model 250 published and newly reported hunter-gatherers dated to 145ka using qpAdm as a mixture of Oberkassel, Sidelkino, GoyetQ2 ancestries, and an ancestry maximized in Anatolian Neolithic farmers (ANF), as a considerable portion of the sequenced hunter-gatherer genomes date after around 8ka, when ANF ancestry started spreading across Europe. I am Tina Huang, PhD, a data scientist, and the director of the Data Science Learning Center at the University of Arizona. 27, 21852193.e6 (2017). eLife 11, e77625 (2022). ADS In article number 2206752, Hao Zeng and co-workers report a soft actuator assembly capable of windassisted dispersal and lift-off/landing action under the control of a light beam.The design is inspired by the seed of dandelion, resembling several biomimetic features, i.e., high porosity, lightweight, and separated vortex ring generation under a steady wind flow. ather than doing some data analysis or looking at trends, we wanted to dedicate this bulletin to seven women in tech, data, and science that you should know about. Details of the modelling are provided in Supplementary Data 3.C. Details on the allele frequency estimates are provided in Supplementary Information, section12, Supplementary Figs. Great explanations and feels like real interviews that helps me warm up myself before the real interview! 12). My name is Tina and I'm a data scientist and YouTuber. Svensson, E. et al. Data warehousing is a field that has to be done right. In other words, youll never have to worry about validity issues or having to re-take the course after a certain amount of time. Highly Influential Citations 3. Its not clear if shell compete for a spot on the top 200, but I bet shell be there. The oldest individual revealing an indistinguishable genetic profile from the Yuzhniy Oleniy Ostrov group is the 11ka Sidelkino individual from Samara in western Russia42. In product development, we do lots of opportunity sizing to decide which features to build and what opportunities to invest in. Ecologizr. Philos. Max Planck Institute for Evolutionary Anthropology. Last Name Huang #8. Sci. 5). During this time agriculture and a sedentary lifestyle spread from Anatolia to Europe. Nat. Genetic analyses of western European individuals associated with the preceding Badegoulian culture might provide clues on the processes that led to the formation of the GoyetQ2 cluster. CAS As she gains working experience with one of the FAANG companies, Tina continues to share interesting details about her career journey with the audience. under exclusive license to Springer Nature Singapore Pte Ltd. 2022 R. Huang et al. ScienceDaily, 1 March 2023. 15-star ratings) or unstructured data (such as social media reviews). Correspondence to a,b, The ancestries of individuals in the GoyetQ-2 cluster and Iberian hunter-gatherers (HGs) (a) and individuals in the Oberkassel cluster (b) were modelled using qpAdm, with Fournol 85 and Arene Candide 16 representing the Fournol and Villabruna ancestries, respectively. Previously worked at Goldman Sachs and the Ontario Institute for . University Universit Chouaib Doukkali; . A deft hand at turning dense and complicated topics into informative and entertaining videos, theres a ton to learn from every single video. It will provide you with confidence and methodology for demonstrating the required skills appropriately. Conversely,additional Oberkassel ancestry is identified in eastern Europe by at least 7.5ka in newly generated genomes from Minino I and Yazykovo from the upper Volga region, whereasa 1,000-years-older individual from Minino I did not have this genetic component. After the LGM, the Epigravettian culture was widespread in southern andsoutheastern Europe. Xinhe Huang - Teaching Assistant - Cardiff University / Prifysgol 6 and Supplementary Fig. 6, 16581668 (2022). Data warehousing is a relatively new field that focuses on the use of large datasets for analytical purposes. Here is a sampling of five herbs that have demonstrated potential immune support benefits: 1. Gonzlez-Fortes, G. et al. Details of the grouping and ROH segments are provided in Data S3.B. The oldest genomes carrying ancestries that derive primarily from the lineage leading to present-day Europeans are Kostenki 14 (from 37ka, with uncertain archaeological association from western Russia), Goyet Q116-1 (35ka, Aurignacian-associated from Belgium) and Bacho Kiro 1653 (35ka, probably Aurignacian-associated from Bulgaria)2,4,8. The formation of human populations in South and Central Asia. All remains were sampled with the approval of the institutions responsible for the analysis of archaeological material. With the statistics f4(Mbuti, Fournol 85; Vstonice, test) and f4(Mbuti, Vstonice; Fournol 85, test), we show that all Vstonice-cluster individuals are significantly closer (|Z|>3) to the Vstonice group (n=5) and the Fournol-cluster individuals are closer to Fournol 85, whereas the geographically intermediate Gravettian-associated Goyet group shows extra affinity to both clusters (Fig. Thisancestry profile survived during the Last Glacial Maximum (25,000 to 19,000 years ago) in human populations from southwestern Europe associated with the Solutreanculture, and withthe following Magdalenian culturethat re-expanded northeastward after the Last Glacial Maximum. My name is Tina and I'm a data scientist at a FAANG company. Many students or recent graduates appreciate her for sharing what helped her break into the field. These authors contributed equally: Cosimo Posth, He Yu, Archaeo- and Palaeogenetics, Institute for Archaeological Sciences, Department of Geosciences, University of Tbingen, Tbingen, Germany, Senckenberg Centre for Human Evolution and Palaeoenvironment at the University of Tbingen, Tbingen, Germany, Cosimo Posth,Dorothe G. Drucker,Herv Bocherens,Christoph Wiing,Nicholas J. Conard&Katerina Harvati, Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany, Cosimo Posth,He Yu,Ayshin Ghalichi,Hlne Rougier,Yilei Huang,Harald Ringbauer,Adam B. Rohrlach,Kathrin Ngele,Vanessa Villalba-Mouco,Rita Radzeviciute,Tiago Ferraz,Alexander Stoessel,Rezeda Tukhbatova,Wolfgang Haak&Johannes Krause, State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, China, Department of Anthropology, California State University Northridge, Northridge, CA, USA, Universit de Bordeaux, CNRS, MC, PACEA UMR 5199, Pessac, France, Isabelle Crevecoeur,Andr Morala,Stphane Madelaine,Priscilla Bayle,Bruno Maureille,Jean-Guillaume Bordes&Mona Le Luyer, School of Mathematical Sciences, University of Adelaide, Adelaide, South Australia, Australia, Instituto Universitario de Investigacin en Ciencias Ambientales de Aragn, IUCA-Aragosaurus, Zaragoza, Spain, Department of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena, Germany, Institute of Zoology and Evolutionary Research, University of Jena, Jena, Germany, Center of Excellence Archaeometry, Kazan Federal University, Kazan, Russia, Department of Biology, University of Florence, Florence, Italy, Martina Lari,Alessandra Modi&Stefania Vai, Estonian Biocentre, Institute of Genomics, University of Tartu, Tartu, Estonia, Tina Saupe,Christiana L. Scheib&Luca Pagani, St Johns College, University of Cambridge, Cambridge, UK, Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Palermo, Italy, Department of Biology, University of Padova, Padova, Italy, Department of Chemistry G. Ciamician, Alma Mater Studiorum, University of Bologna, Bologna, Italy, Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany, UMR 8068 CNRS, TEMPSTechnologie et Ethnologie des Mondes Prhistoriques, Nanterre Cedex, France, Laurent Klaric,Olivier Bignon-Lau,Grgory Debout,Michel Orliac,Pierre Bodu,Bndicte Souffi&Frdrique Valentin, Muse National de Prhistoire, Les Eyzies de Tayac, France, UMR 5140 CNRS, Archologie des Socits Mditerranennes, Universit Paul-Valry, Montpellier, France, UMR 7194, Histoire Naturelle de lHomme Prhistorique (HNHP), Dpartement Homme et Environnement, Musum National dHistoire Naturelle, CNRS, UPVD, Paris, France, Association APRAGE (Approches pluridisciplinaires de recherche archologique du Grand-Est), Besanon, France, Skeletal Biology Research Centre, School of Anthropology and Conservation, University of Kent, Canterbury, UK, Dipartimento di Scienze Fisiche, della Terra e dellAmbiente, U.R. In the MDS plot (Fig. Then we merged the genotypes from different libraries of the same individual, by randomly picking alleles from available genotype calls, using a custom script. Wow! Details are provided in Data S2.B. Separating endogenous ancient DNA from modern day contamination in a Siberian Neandertal. Ace the SQL part of any data science job interview and get hired. Conversely, the ancestry found in pre-30ka eastern European individuals (Kostenki cluster and Sunghir group) contributed to Gravettian-associated individuals from central and southern Europe (Vstonice cluster), the latter without descendantsretrieved in post-LGM populations from those regions. First, we show that individuals associated with the Gravettian culture across Europe were not a biologically homogeneous population. Tina Huang is one of the top three students to show up to compete. 9) and testing the relative affinity among them using f4-statistics in the form f4(Mbuti, Epigravettian A; Epigravettian B, Epigravettian C) (Supplementary Data 2.E). The Gravettian culture was one of the most widely distributed Upper Palaeolithic cultures across western Eurasia before the LGM19. PubMed Central As previously hinted37, we find a large frequency variation in alleles related to skin and eye pigmentation among post-LGM hunter-gatherer groups. The indexed products for each library were pooled, purified over MinElute columns (Qiagen), eluted in 50l TET and again quantified using the IS5 and IS6 primers59 using the quantification method described above. Edgar, R. C. MUSCLE: multiple sequence alignment with high accuracy and high throughput. For ds_halfUDG libraries, we masked 2bp from both ends of the reads with trimBam in bamUtil 1.0.13 (https://github.com/statgen/bamUtil) to remove the damaged sites. Notably, and contrary to the report by Fu et al.4, another Gravettian-associated population from centralwestern Europe (Goyet in Belgium, n=6 individuals) is both geographically and genetically intermediate between the Vstonice and Fournol clusters. We built 1 to 8 single- and double-stranded genetic libraries for each individual and enriched them for human DNA on 1.24million single nucleotide polymorphisms6 (SNPs), which were then sequenced and yielded 0.04- to 7.64-fold coverage on average over the targeted SNPs. You probably remember me from class or an event, and that's why this profile is so interesting - it traces my journey from student-athlete at the University of California Davis into a successful entrepreneur with multiple ventures under her belt by age 25, Your email address will not be published. 2022 Fab Business Solutions - All Rights Reserved. In this video, I had the opportunity to talk with Tina Huang, a Data Scientist at one of the FAANG companies. Tina: Creates YouTube videos with millions of views on data science careers, learning to code, SQL, productivity, and study techniques. Paradis, E., Claude, J. Between 14 and 8ka, all hunter-gatherers in western and central Europe carried only Oberkassel ancestry, with no detectable contribution from the Sidelkino cluster. Rep. 11, 15005 (2021). Everything you need to know is included in the course. With a lot of raw data, you need to put in some work. Tina Llorca CPA, CWP, CEPP, CIS, MDRT Ampliar bsqueda. The science policy "Framework for Federal Scientific Integrity Policy and Practice" issued by the White House Office of Science and Technology Policy a day later is criticized as a "gag order" on scientists by PEER in an open letter (30 Jan). Tina Huang: Data science, computer science, and career advice expert. The black-outlined diamond marked out in the Gravettian group shows the PMR between the two Gravettian-associated individuals from southern Italy (Paglicci 12 and Ostuni 1). This, together with the evidence of Villabruna ancestry in El Mirn 19ka, further suggests that this genetic discontinuity could be the result of palaeogeographic and palaeoecological transformations connected to the LGM32, rather than to the BllingAllerd warming period4,15 (14.712.9ka).
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