Individual doses of 2 mL or less may be given on a daily basis until the calculated total amount required has been reached. Use Caution/Monitor. rabeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. commonly, these are "preferred" (on formulary) brand drugs. calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. iron sucrose increases levels of calcium acetate by enhancing GI absorption. Applies only to oral form of both agents. Human studies not conducted. Please confirm that you would like to log out of Medscape. Parenteral iron supplementation. iron sucrose, benazepril. Iron sucrose | Drugs | BNF | NICE For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. (See also Notes section. Foods rich in iron include meats (especially liver), eggs, raisins, figs, broccoli, brussels sprouts, beans, lentils, and iron-fortified or enriched cereals. Ferrlecit may be diluted in 100 mL of 0.9% sodium chloride administered by intravenous infusion over 1 hour per dialysis session. The dosage of Venofer is expressed in mg of elemental iron. Drug Des Devel Ther; 5: 5160. The normal ranges are: for males 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and for females 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L). Drug: Comments: A: Acyclovir 1: Dose using a 40% adjusted body weight; Amikacin 2: Dose using a 40% adjusted body weight; Amphotericin B (liposomal) 3 Consider capping body weight to 100 kg; Atracurium 4: Dose using ideal body weight; The use of ideal body weight has been shown to be associated with a more predictable muscle strength recovery within 60 minutes and a lack of need for antagonism . Minor/Significance Unknown. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. STORAGE: Consult the product instructions and your pharmacist for storage details. Koch TA, Myers J, Goodnough LT. Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Copyright 2014 - 2023 The Calculator .CO |All Rights Reserved|Terms and Conditions of Use, Parenteral Iron Replacement For Iron Deficiency Anemia Calculator, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Clinical use of the total dose intravenous infusion of iron dextran, When is high-dose intravenous iron repletion needed? Divide the calculated dose by the patient's weight (IBW if BMI >30, or actual body weight (ABW) if BMI30) to ensure it does NOT exceed 20mg/kg. iron sucrose decreases levels of penicillamine by inhibition of GI absorption. . Monitor Closely (1)iron sucrose decreases levels of thyroid desiccated by inhibition of GI absorption. Intravenous iron sucrose for children with iron deficiency failing to Maximum infusion rate: 100 mg / hour (Slow infusion rate of iron sucrose is recommended to minimize adverse reactions, especially hypotension) Frequency of infusion: Dose may be repeated up to 3 times weekly to provide total iron dose. Applies only to oral form of both agents. This health tool computes the iron deficit based on patient parameters and the Ganzoni formula. 2012;2(4):288-335. Allow at least 30 minutes between administration of Feraheme and administration of other medications that could potentially cause serious hypersensitivity reactions and/or hypotension, such as chemotherapeutic agents or monoclonal antibodies. Initial symptoms may include hypotension, syncope, unresponsiveness, cardiac/cardiorespiratory arrest. Avoid or Use Alternate Drug. The dosage of Venofer is expressed in mg of elemental iron. Monitor Closely (1)trientine, iron sucrose. Avoid or Use Alternate Drug. PRECAUTIONS: Before using iron sucrose, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. Initial infusion rate. By clicking send, you acknowledge that you have permission to email the recipient with this information. Monitor Closely (1)vitamin E decreases levels of iron sucrose by increasing hepatic clearance. Applies only to oral form of both agents. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Interaction only with oral iron administration. Both the 200- and 300-mg doses of IV iron sucrose administered over 2 hours appear to be safe. Monitor Closely (1)famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Consult your doctor before breast-feeding. Applies only to oral form of both agents. Applies only to oral form of both agents. nizatidine will decrease the level or effect of iron sucrose by increasing gastric pH. J Lab Clin Med; 111(5):566-70. Ganzoni Equation for Iron Deficiency Anemia - MDCalc Use Caution/Monitor. The dose of Ferinject is based on calculation of ideal body weight and calculation of iron deficit using the Ganzoni formula. Iron Product. Avoid or Use Alternate Drug. By taking into account the case of a patient weighing 78 kg (172 lbs) and having a hemoglobin level of 11 g/dL (110 g/L or 6.83 mmol/L). Hollands J, Foote E, Rodriguez A. Minor (2)calcium gluconate decreases levels of iron sucrose by inhibition of GI absorption. Diluted with 0.9% Sodium Chloride Injection at concentrations of 1 to 2 mg/mL, 2 doses of 300 mg/250 mL over 1.5 hrsplus1 dose of 400 mg/250 mL over 2.5 hrs. Finally, a 400-mg dose by 2-hour infusion was examined in 35 patients, but 2 patients experienced such symptoms as hypotension, nausea, and lower back pain. Iron Sucrose Protocol - Cmqcc Applies only to oral form of both agents. Dosing for patients who weigh 50 kg or more For patients weighing 50 kg (110 lb) or more: Give Injectafer in two doses separated by at least 7 days. Use Caution/Monitor. Minor/Significance Unknown. Separate by 2 hr. Patients with a history of drug allergy or multiple drug allergies may be at increased risk of anaphylactic-type reactions to INFeD. For additional Safety Information, please see Full Prescribing Information. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Venofer [package insert]. HOW TO USE: This medication is given by injection into a vein as directed by your doctor. Replacement of iron stores found in hemoglobin, myoglobin, and enzymes; works to transport oxygen via hemoglobin, Do not mix with other medications or add to parenteral nutrition solutions for IV infusion, Do not dilute to concentrations below 1 mg/mL, Add dose to 0.9% NaCl infusion bags (PVC or non-PVC); final concentrations range is 1-2 mg of elemental iron/mL, Visually inspect for particulate matter and discoloration prior to infusion, Stable for 7 days at controlled room temperature (25C). didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. Med J Aust; 193(9):525-32. Recommended dosage for patients weighing less than 50kg (110lb): Give Injectafer in Monitor Closely (1)calcium carbonate will decrease the level or effect of iron sucrose by increasing gastric pH. * Adapted from the KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease. Monitor Closely (1)sodium sulfate/?magnesium sulfate/potassium chloride decreases levels of iron sucrose by inhibition of GI absorption. Mean Corpuscular Hemoglobin Concentration (MCHC) Calculator, Red Blood Cell (RBC) Indices Calculator, Iron Deficiency In Pregnancy Calculator. NOTES: Lab and/or medical tests (such as complete blood count, ferritin, transferrin, total iron binding capacity-TIBC) should be done while you are using this medication. Applies only to oral form of both agents. Minor/Significance Unknown. iron sucrose decreases levels of moxifloxacin by inhibition of GI absorption. Compare formulary status to other drugs in the same class. (2010) Diagnosis and management of iron deficiency anaemia: a clinical update. This drug is available at a higher level co-pay. Applies only to oral form of both agents. Minor/Significance Unknown. For adult CKD patients on ESA therapy who are not receiving iron supplementation, the guideline suggests a trial of IV iron (or in NDD-CKD patients, alternatively, a 1- to 3-month trial of oral iron therapy) if: CKD=chronic kidney disease ESA=erythropoietin-stimulating agent Hb=hemoglobin IV=intravenous RBC=red blood cell WBC=white blood cell. Monitor Closely (1)rabeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. PDF Injectafer (ferric carboxymaltose injection) - Food and Drug Administration Andreas M. Ganzoni, MD, is a physician and researcher in the internal medicine department at the University of Zurich in Zurich, Switzerland. elemental iron (mg/ml) in the product being used: Where C= Serious - Use Alternative (1)iron sucrose decreases levels of gemifloxacin by inhibition of GI absorption. 1000 mg. 20 MINUTES. Chandler G, Harchowel J, Macdougall I. Monitor Closely (1)iron sucrose decreases levels of penicillamine by inhibition of GI absorption. This drug is available at a middle level co-pay. Minor/Significance Unknown. The therapeutic management of IDA focuses on the replenishment of the iron stores through methods that have been mentioned above. Adding plans allows you to compare formulary status to other drugs in the same class. Avoid or Use Alternate Drug. Either increases effects of the other by pharmacodynamic synergism. Venofer (iron sucrose) 20 mg iron / ml, solution for injection or Although anaphylactic reactions known to occur following INFeD administration are usually evident within a few minutes, or sooner, it is recommended that a period of an hour or longer elapse before the remainder of the initial therapeutic dose is given. The plasma ferritin level as a reliable index of body iron stores following intravenous iron dextran. Administer Venofer only intravenously by slow injection or by infusion. PDF Venofer Guidelines for Use 2011 - University Health System Contact the applicable plan Venofer is manufactured under license from Vifor (International) Inc., Switzerland. Anemias. Challenges in the treatment of iron deficiency include finding and addressing the underlying cause and the selection of an iron replacement product that meets the needs of the patient. Diagnosis and management of iron deficiency anaemia: a clinical update. Applies only to oral form of both agents. iron sucrose increases levels of calcium carbonate by enhancing GI absorption. Venofer treatment may be repeated if necessary. Dose administration to an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy. iron sucrose, captopril. Avoid or Use Alternate Drug. Intravenous (IV) iron products (use in adults) Dosing information in this table is for adults and includes some dosing recommendations not listed in the approved product information. These adverse reactions have occurred up to 30 minutes after the administration of Venofer injection. The above information is provided for general 4. Iron Sucrose - Injection - Alberta Administer on 5 different occasions over a 14 day period. Next Steps Evidence Creator Insights Dr. Andreas M. Ganzoni About the Creator In less advanced cases of iron deficiency, increases in dietary intake of iron may be sufficient. Most Elemental iron product this is a choice between three iron supplement products: Iron dextran 50 mg/mL, Iron sucrose 20 mg/mL and Ferric gluconate 12.5 mg/mL. Avoid or Use Alternate Drug. Applies only to oral form of both agents. Where C is the concentration of the iron product: Please note that the calculations above are for information purposes only and the individual dose needs to be established by taking into account the current package insert for the elemental iron product used. 2 *Venofer is an iron replacement product indicated for the treatment of iron deficiency anemia in patients with CKD. Applies only to oral form of both agents. 2.1 Dosage - Total dose infusion The dose calculation for CosmoFer is based on patients body weight according to the table below and is diluted in 500mLs of normal saline. Applies only to oral form of both agents. Applies only to oral form of both agents. calcium chloride decreases levels of iron sucrose by inhibition of GI absorption. We'll do this entirely for free, as long as the calculator has applications for women's health. Fatal reactions have followed the test dose of iron dextran injection. Iron deficiency can occur at any stage of life, due to physiological demands, for example, during pregnancy, childhood growth or prolonged periods of sickness. Use Caution/Monitor. IDA symptoms are often nonspecific and include tiredness, weakness, shortness of breath. Applies only to oral form of both agents. Most For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every two weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores The recommendation is that most adults need a cumulative dose of elemental iron of at least 1 g. Avoid or Use Alternate Drug. Estimates the iron deficit in preparation for iron replacement based on patient weight and haemoglobin. Your doctor will do laboratory tests to monitor your response. Dosage Calculator Oral and parenteral products - see background option for oral products. Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. 1970;100(7):301303. Equations : Total body iron deficit (mg) = body weight (kg) x (target Hb - actual Hb in g/dL) x 2.4 + iron depot (mg)** [1, 2] Iron depot: 15 mg/kg for body weight less than 35 kg 500 mg for those with a body weight greater than or equal to 35 kg Ideal Body Weight (kg) =45.5 +2.3 * (height inches - 60 inches) [3] PDF Highlights of Prescribing Information Contraindications- Venofer Generic name: IRON SUCROSE 20mg in 1mL Applies only to oral form of both agents. Hanson DB, Hendeles L. Guide to total dose intravenous iron dextran therapy. Use Caution/Monitor. Information last revised December 2022. Where C= concentration of elemental iron (mg/ml) in the product being used: Data from Ferrlecit postmarketing spontaneous reports indicate that individual doses exceeding 125 mg may be associated with a higher incidence and/or severity of adverse events, Adult Patients with Hemodialysis Dependent-Chronic Kidney Disease (HDD-CKD), Adult Patients with Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD), WARNING: RISK FOR SERIOUS HYPERSENSITIVITY/ANAPHYLAXIS REACTIONS, Iron Deficiency and Anemia- signs and therapeutic options. Monitor for signs and symptoms of hypotension following each administration of Venofer. HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication. Safety of highdose iron sucrose infusion in hospitalized patients with chronic kidney disease. There are four variables, all patient parameters, required in the iron deficiency calculator: The patients weight is used in the Ganzoni equation and also when establishing the iron stores. Formula for calculating the required dose of iron sucrose 1. Monitor Closely (1)deferasirox decreases levels of iron sucrose by inhibition of GI absorption. Congenital Pulmonary Airway Malformation Volume Ratio (CVR) Calculator -. Applies only to oral form of both agents. feasible, Maximum total cumulative iron sucrose dose administered in 14 days is 1000 mg elemental iron. FERAHEME vs Venofer (iron sucrose) - Feraheme DICP. Option 2: 200 mg in NS 100 mL administered over 20-30 minutes; may repeat every other day to Nutrition. Use Caution/Monitor. Deferasirox chelates iron. The recommendation is that most adults need a cumulative dose of elemental iron of at least 1 g. Iron replenishment can be done intravenously, either as total dose (example: iron-dextran or iron carboxymaltose) or as split dose (example: iron sucrose). All Rights Reserved. Fulminant symptoms include confusion, sensation of passing out, paleness. Venofer and the Venofer logo are registered trademarks of Vifor (International) Inc., Switzerland. provider for the most current information. Manage and view all your plans together even plans in different states. Use Caution/Monitor. Monofer 100mg/ml solution for injection/infusion - Summary of Product Serious - Use Alternative (1)iron sucrose decreases levels of ciprofloxacin by inhibition of GI absorption. Iron metabolism needs to be balanced and bleeding, the major cause of iron deficiency (for instance in menstruation in females and chronic occult gastrointestinal bleeding) needs to be addressed. Use Caution/Monitor. Intravenous iron replacement can take place as total dose (as in the case of iron-dextran or iron carboxymaltose) or as split dose (in the case of iron sucrose). ]Venofer treatment may be repeated if iron deficiency reoccurs. Taking the case of a patient weighing 75 kg (165.3 lbs) with a target hemoglobin value of 13 g/dL (130 g/L or 8.07 mmol/L), an actual hemoglobin of 9.5 g/dL (95 g/L or 5.9 mmol/L) and iron stores of 500 mg, the iron deficit is: Iron deficit = 75 x (13 9.5) x 2.4 + 500 = 1,130 mg. In case a pediatric patient with a weight below 35 kg is assessed, iron stores are calculated as 15 mg iron for each kg. (1970) Intravenous iron-dextran: therapeutic and experimental possibilities. Adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight. PDF Protocol for the use of Intravenous Iron Dextran (CosmoFer Applies only to oral form of both agents. Venofer Injection Prescribing Information - Drugs.com Coadministration of ciprofloxacin with multivalent cation-containing products may reduce the bioavailability of ciprofloxacin by 90%. You will have to pay for your IV iron. vitamin E decreases levels of iron sucrose by increasing hepatic clearance. Ren Fail. Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling (16.2).]
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